One minute videos explaining what researchers are investigating Donald Davidson describes his research on the physiological importance and therapeutic potential of host defence peptides in protection against bacterial and viral infections. HTML Document Donald Davidson video transcript (11.81 KB / DOCX) Julia Dorin describes how Defensins are a family of small proteins (peptides), important in innate immunity that help protect us from infection. In addition to direct pathogen killing they have additional functions in immunity and a novel function in male fertility. Understanding how these molecules work will lead to new therapeutic avenues of research. HTML Document Julia Dorin video transcript (11.86 KB / DOCX) Sarah Howie describes her groups research on women's response to vaccination against the cancer causing type of papillomavirus. HTML Document Sarah Howie video transcript (11.68 KB / DOCX) Philippa Saunders describes her research on how the sex steroid hormones oestrogen and testosterone play a key role in regulating our fertility, our moods, our bones, our immune systems and disorders such as cancer. HTML Document Philippa Saunders video transcript (11.58 KB / DOCX) Chris Gregory describes how cell birth and cell death are normally kept in balance in our tissues but, in cancer, imbalances favouring expansion of cell populations occur. His research investigates the underlying mechanisms and, in particular, how dying tumour cells can drive expansion of malignant cell populations. HTML Document Chris Gregory video transcript (11.61 KB / DOCX) Steve Jenkins describes his groups research on how tissue macrophages are generated and controlled in order to understand how to they can be manipulated during inflammatory disease. HTML Document Steve Jenkins video transcipt (11.79 KB / DOCX) David Kluth describes how macrophages genetically modified to express heme-oxygenase-1 (HO-1) reduce experimental acute kidney injury (AKI). Furthermore drugs such as heme arginate, which up-regulate, HO-1 can protect from AKI and are now being tested in renal transplantation. HTML Document David Kluth video transcript (11.92 KB / DOCX) Stephen Wigmore describes how his group investigate the mechanisms causing damage to organs in surgery and research techniques and new drugs to protect organs from damage in surgery and transplantation. HTML Document Stephen Wigmore video transcript (11.82 KB / DOCX) This article was published on 2024-09-10