This theme investigates how tissues respond to inflammatory injury and the long-term effects of chronic inflammation. Researchers study the cellular and molecular mechanisms behind tissue damage, repair, and regeneration across organs such as the liver, kidney, lung, and skin.A key focus is understanding how chronic inflammation contributes to human diseases like chronic liver disease, chronic kidney disease, skin chronic wounds, pulmonary fibrosis and cancer, including the roles of ageing cells, impaired repair, dysregulation of immune cells, and cell interactions that lead to scarring. Using advanced tools to study individual cells and their locations in the body, our research helps reveal promising targets for future therapies.Key areas of focusLong-term (chronic) inflammationConsequences of inflammationChronic inflammation in the context of autoimmunityTissue repair and regenerationDamage or injury to tissueApplication to liver, kidney, lung, skin and cancerAdvanced tools to study individual cells and their locations within tissues, in both human samples and preclinical modelsIdentifying therapeutic targets to treat diseases caused by chronic inflammation and improper healing of tissuesTheme Leads: Prakash Ramachandran and Sonja Vermeren Immunofluorescence image of a diabetic foot ulcer (credit: Dr Jenna Cash) This article was published on 2025-06-11