Research groups

We study how cells in the tumour microenvironment influence tumour progression and outcomes in patients with lung cancer

We study how gut microbes interact with dying intestinal cells and explore what drives infections and microbial imbalances in the gut, aiming to develop new treatments that prevent infections and reduce intestinal damage

My laboratory is interested in diagnostics innovation in the context of targeted and effective antibiotic therapy

Translational genomics in critical illness

My research focuses on the use of novel biomarkers to better understand kidney injury and ageing

Abi's research programme aims to improve care for critically ill patients globally, by establishing mechanisms for continuous data driven evaluation, evidence generation and practice change within routine care. Abi's core work focuses on implementing and using the components of learning health systems to generate data driven research to address inequalities in critical care outcomes.

Tom Bird’s group studies abnormal liver regeneration particularly in liver cancer: hepatocellular carcinoma. We specialise in complex genetically engineered preclinical models developed around human drivers of this cancer.

Debby Bogaert's group focuses on investigating the physiology and pathophysiology of respiratory infections and inflammation from an ecological perspective.

Jenna Cash's research focuses on understanding the events that determine whether a skin wound will heal acutely or develop into a chronic non-healing wound.

Acute respiratory disease in children, particularly in relation to early viral infection, asthma, cystic fibrosis and rare lung disease. Early Phase clinical trials.

Kev Dhaliwal's group investigates Disruptive Technologies to Advance Respiratory Medicine and Critical Care.

He directs the Translational Healthcare Technologies Group (www.tht.ac.uk) with a focus on early phase experimental medicine and team science.

Investigating macrophages in host defence against bacteria and viruses with emphasis on microbicide mechanisms and cell death paradigms in pulmonary infection and human immunodeficiency virus (HIV).

We largely focus on establishing the role of intrinsic mechanisms that contribute to the evolution of antibiotic resistance, fitness and survival in gram-negative bacteria.

Julia Dorin's research focus is on the function of host defence peptides by studying the consequence of their dysfunction in the mouse. Currently this approach is revealing their involvement in infertility, obesity and immunomodulation.

Rodger Duffin's research interests are focused on the mechanisms controlling inflammatory processes from initiation to resolution and also understanding the potential toxicology surrounding environmental and occupational nanoparticle exposures.

Joy Edwards-Hicks’ group investigates how age-related metabolic changes impact lymphocyte signalling and function.

Translational Liver Research

Yi Feng's group studies in vivo live imaging and genetic analysis of the earliest events of tumour initiation with the emphasis on the influence of inflammation to cancer progression in a zebrafish model.

David Ferenbach’s group is focussed on understanding the impact of senescence on the ageing and injured kidney - and how signalling from senescent cells contribute to multi-organ fibrosis, dysfunction and multi-morbidity.

We aim to revolutionize the current perception of ageing - as an inevitable process - and provide new tools to increase regeneration and promote greater ''health span'' for the next generation.

Malawi Accelerated Research in Vaccines by Experimental and Laboratory Systems (MARVELS) and Experimental Medicine in Respiratory Infection

Carsten Gram Hansen studies the cellular functions regulated by and of the Hippo Pathway

Investigating the pathogenesis of autoimmune rheumatic diseases, including rheumatoid arthritis (RA), Sjögren’s syndrome, and systemic lupus erythematosus (SLE)

Christopher D Gregory's lab aims to understand the mechanisms by which apoptotic tumour cells condition the tumour micro-environment.

My laboratory focuses on the viral host factors determining pathogenicity and susceptibility.

Rashan's research focus is to improve care for critically ill patients globally by enabling a community of practice that uses a common data platform for continuous data driven evaluation, evidence generation and practice change.

Neil Henderson's lab is interested in the cellular and molecular mechanisms that drive organ fibrosis, and also the pathways which are responsible for efficient wound healing and healthy tissue regeneration following injury.

Nik Hirani's group are interested in the mechanisms that regulate inflammation in the lung and how these can be modified so that inflammation resolves without scarring or damaging the lung.

The use and development of single-molecule and super-resolution microscopy to answer biological questions, with a focus on neuroscience and neurodegeneration.

Steve Jenkins is investigating the functional diversity of myeloid cells in tissue homeostasis and immune regulation, with a major focus on the mechanisms that maintain tissue resident macrophages under steady state and inflammatory conditions.

Tim Kendall is interested in the role of WT1 in liver fibrosis and regeneration, exploring myofibroblast heterogeneity throughout the entire disease process.

My research interests are in surgical robotics and image-guided therapies. Our projects typically involve the design and modelling of robotic systems for less invasive and/or more accurate surgery.

Wei-Yu Lu’s group studies the role of T cells in modulating liver epithelium regeneration.

My lab is interested in the immunology of tissue regeneration within the injured lung.

We study rare genetic inflammatory conditions associated with lung inflammation to understand more about how these conditions occur, with the aim of identifying new therapeutic targets.

We are focused on understanding the molecular mechanisms that allow Candida albicans to successfully exploit the host and cause disease, and are investigating new strategies to combat antifungal drug resistance.

My research is focused on the effects of stroke on systemic immune function and how this contributes to complications of stroke recovery, including infection, gastrointestinal dysfunction and fatigue.

Studying microbial keratitis (infection of the cornea) through molecular characterisation of the disease and health-system mapping methodologies to enable scalable and responsible translation of public health interventions, diagnostic development and treatment strategies.

My research interest is understanding how critical illness, in particular critical illness-induced bone marrow hypoxia, alters monopoeisis and whether this has long-term consequences for immunity in ICU survivors.

Damian’s research is driven by a vision to produce innovative solutions to difficult health and societal problems and challenging diseases. His entrepreneurial research strategy is based on a critical questioning approach, disease mechanism evaluation and seeking out and building the best teams to discover and deliver these solutions.

Damian’s current research includes understanding why people who have sustained significant inflammation have diminished overall survival and poor organ performance.

We study how immune cells called phagocytes kill and digest different micro-organisms, with the ultimate aim of developing new drugs that could be used to resolve inflammation and persistent infections

My goal is to contribute to the fields of immunology and ageing. I wish to investigate the role of senescence cell and immune cell interactions in regeneration in kidney and heart disease, and how anti-senescence treatments can play a part in improving outcomes for patients.

Clare’s research focuses on understanding the role of CSF1R signalling during macrophage development.

To study immune regulation of organ fibrosis with a view to identifying novel anti-fibrotic therapeutic approaches.

Adriano Rossi's lab aims to gain a better understanding of the mechanisms controlling inflammatory processes with a view to help develop novel therapies for chronic inflammatory diseases.

Jürgen Schwarze's group studies immune mechanisms of viral bronchiolitis and the role of virus induced immune modulation in allergy and asthma focusing on the innate/adaptive immune interface in the lung.

Manu's research programme aims to enable precision immunomodulation in critically ill adults with sepsis and acute respiratory distress syndrome (ARDS). Manu's core hypothesis is that modifiable biological networks generate clinical phenotypes, and such networks could be determined by integration of clinical and immunobiology data.
Manu leads a globally unique precision medicine programme focussed on critically ill adults: The TRAITS Programme. See Link below.

We study how our immune system and antiviral therapeutics work to inhibit virus replication.

We study bacterial pathogens that cause disease in humans and animals, aiming to develop better ways to control and treat infections

Marc Vendrell's lab studies dynamic activatable fluorophores for real-time imaging of molecular events in inflammatory diseases and experimental therapeutics.

My research interest is focussed on the molecular control of pro- and anti-inflammatory neutrophil functions in health and disease and neutrophil dysregulation in disease.

We study how immune cells called neutrophils detect and respond to changes in oxygen and nutrient levels, and aim to uncover treatments for lung diseases

Chair of Medical and Veterinary Molecular Epidemiology

My research has two focuses: the effect of ultraviolet on systemic health; and on eczema.

My research focuses on understanding the role of neutrophil metabolic signalling pathways in sensing the extracellular microenvironment and driving neutrophil phenotype and function in the lung.

Immune cell migration during inflammation and infection.

Chengcan Yao's lab studies the roles of bioactive lipids in modulation of immunity and inflammatory diseases in barrier tissues.