By assembling a team of expert clinicians and scientists we aim to understand the key features of COVID-19. Ultimately this information will help to inform the development of better tests and therapeutic interventions for these conditions. What are ICECAP core research activities? Our core ICECAP research deliverables include: Histopathological description of severe COVID-19 from post-mortem, and correlation to clinical and scientific characteristics Immune and parenchymal cell phenotyping from multiple organs by techniques including (but not limited to) multiplex immunofluorescence, flow cytometry, microscopy, proteomics and single cell RNA sequencing Viral tissue tropism (in multiple organs) and determining presence of live virus Spatial distribution of virus (multiple organs) Analysis of host and viral factors that influence severity and outcome from COVID-19 ICECAP research depends on the generosity of donors and their families who make the valuable gift of tissue after death. ICECAP funding and support ICECAP receives funding and support from: The Chief Scientist Office LifeArc Medical Research Scotland This article was published on 2024-09-10
