Manu's research programme aims to enable precision immunomodulation in critically ill adults with sepsis and acute respiratory distress syndrome (ARDS). Manu's core hypothesis is that modifiable biological networks generate clinical phenotypes, and such networks could be determined by integration of clinical and immunobiology data. Manu leads a globally unique precision medicine programme focussed on critically ill adults: The TRAITS Programme. See Link below. Professor Manu Shankar-Hari Chair of Translational Critical Care Medicine / Honorary Consultant in Intensive Care Medicine Contact details Admin Support - Daga Harezga: dharezga@ed.ac.uk Web: TRAITS Programme Group MembersPost-doctoral researchersDr Jennifer RynneDr Mia MosavieDr Peter Smith PhD Students (Thesis topic)Dr Rohit Saha (Design characteristics of ARDS RCTs)Ms Renske Hoekstra (MRC Precision Medicine Studentship) - Identifying molecular subtypes of critical illness to inform better treatments using a precision medicine framework.Ms Saule Zubyte - Role of cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway in acute organ injury in critically ill patients Clinical Trial managersFiona Wee (TRAITS Trial)Dr Kay Russell (GuARDS Trial)Emily Lynch (TRAITS Trial)Pina Sorbara (GuARDS Trial)Research OverviewCritical illness is a major cause of morbidity and mortality globally. Even for the two most common critical illness syndromes - sepsis and acute respiratory distress syndrome (ARDS) - there are no effective treatments other than supportive care.My lab pursues the hypothesis that critical illnesses reflect perturbations within intracellular and intercellular networks that link cells, and organ systems. Illness networks arise from functional interdependencies between the molecular components within human cells. Many of these illness networks are causal and determine clinical phenotypes. Thus, my lab's two focussed research themes of immunobiology and epidemiology converge to a core aim of determining these observable and treatable immunological abnormalities in critical illness (treatable traits).The immunobiology focus of my lab are the phenotypic and molecular changes in T and B lymphocytes during critical illness and resolution from critical illness, to determine modifiable changes that could improve patient outcomes. This information is used to design seamless early to late phase human randomised clinical trials to translate immune changes into treatments for patients.TRAITS Programme Image Biographical ProfileManu Shankar-Hari trained in Intensive Care Medicine in London, completed MSc in Epidemiology from the London School of Hygiene and Tropical Medicine, and did his PhD in Immunology at the Peter Gorer Department of Immunobiology at King's College London, UK.Honours and Awards2019 - Lowry Fink Fellowship, International Sepsis Forum2017 - Global Rising Star in Intensive Care, Australia and New Zealand Intensive Care Society2016 - NIHR Clinician Scientist FellowshipAlumniPost-doctoral researchers [Current position]Dr Michael Carter, NIHR ACL [Consultant in Paediatric ICM, at Imperial College London]Dr Silvia Cellone-Trevelin [Research Integrity Specialist, UK]Dr Yasmeen Ghnewa [Research Manager, Action Medical Research]Dr Liang Ma, [Scientist, Imperial College London]PhD students (Thesis title) [Current position]Dr Matthew Fish (Longitudinal immune monitoring to identify immune states in sepsis). [PDRA at Tomic Lab, NIEDL, Boston].Dr Aislinn Jennings (Characterisation of Lymphocyte receptor repertoire in sepsis).Dr Muska Miller (The role of antibiotics, catecholamines and sedatives on immune cell functionality and mitochondrial activity). [ICM Training in London]Dr Miranda J Melis (Interplay between stress hormones, mitochondria, and immune cells during sepsis). [Medical student at Netherlands]Dr Vera Peters (Fatty acids at cross roads of immune, and metabolic pathways in sepsis). [PDRA in Experimental Cardiology in Cologne, Germany]Pre-doctoral researchers [Current position]Ms Carolyn Lam (Scientist at Astrazeneca)Other Responsibilities InternalAssociate Director, ECAT-I: Wellcome Trust PhD Programme for Health ProfessionalsAcademic Steering Committee, Precision Medicine Doctoral Training Programme External Editor responsibilitiesDeputy Editor, ThoraxAssociate Editor, Intensive Care Medicine Funding committeesBoard Member, EME Funding CommitteeChair, EME Advanced Fellowships Joint Funding CommitteeOther rolesCo-Director of Research, UK Intensive Care SocietyMember, WHO Clinical Guideline Development GroupDomain lead and Member, International Trial Steering Committee, REMAP-CAP TrialCouncil, International Sepsis Forum Trustee, Board of Management, Intensive Care National Audit and Research Centre CollaboratorsInternalProfessor Adriano Rossi, University of EdinburghProfessor Kev Dhaliwal, University of EdinburghDr Sohan Seth, University of EdinburghProfessor Kenneth Baillie, University of EdinburghProfessor Rashan Haniffa, University of EdinburghDr Abi Beane, University of EdinburghProfessor Christopher Weir, University of EdinburghDr Karen Mackenzie, University of EdinburghDr Nazir Lone, University of EdinburghDr Annemarie Docherty, University of EdinburghDr David Griffith, University of EdinburghExternalICNARCProfessor Jo SpencerDr Chad SwansonCarolyn CalfeeCharlotte Summers Cecilia O’Kane Francois Lamontagne (Canada) Iain McInnesDanny McAuley Julian Knight Intensive Care National Audit and Research Centre View all publications on Research Explorer FundingManu's group is funded primarily by grants from the NIHR; NIHR HTA programme; MRC-EME programme; MRC; National Institute of Academic Anaesthesia; HDR UK; UKRI COVID-19 FundingSources of funding held in CIR :NIHR HTA programmeMRC-EME programmeHDR UKChief Scientist Office This article was published on 2024-09-10
