We largely focus on establishing the role of intrinsic mechanisms that contribute to the evolution of antibiotic resistance, fitness and survival in Gram-negative bacteria. What makes bacteria resist antibiotics and evade the immune system? We tackle this question by studying the hidden mechanisms that allow the bacteria Klebsiella to cause serious infections by outsmarting human defences and antibiotic therapy. Our discovery of the role of the protein RamA, in modifying lipopolysaccharides (components in the outer coating of Klebsiella) provides new insights into how this bacteria alters itself to survive in the human host. Dr Thamarai Schneiders Principal Investigator Centre for Inflammation Research Institute for Regeneration and Repair Contact details Email: Thamarai.Schneiders@ed.ac.uk Research Interests Dr Schneiders' research largely focusses on establishing the role of intrinsic mechanisms that contribute to the evolution of antibiotic resistance, fitness and survival in Gram-negative bacteria.Research themeInfection and immunityLab MembersOliver Coombs OBrien, PhD studentHanna Lui, PhD studentTurner Sam, PhD studentPast Lab MembersCharlie Metcalf, Research TechnicianTom Stanton, PhD studentPublicationsPulication list on Edinburgh Research Explorer This article was published on 2024-12-10
