Damage and repair

We aim to better understand how tissues respond to inflammatory injury and the long-term effects of chronic inflammation to reveal targets for future therapies

Cellular and molecular mechanisms 

We study the cellular and molecular mechanisms behind tissue damage, repair, and regeneration across organs such as the liver, kidney, lung and skin. 

A key focus is understanding how chronic inflammation contributes to human diseases like chronic liver disease, chronic kidney disease, skin chronic wounds, pulmonary fibrosis and cancer, including the roles of ageing cells, impaired repair, dysregulation of immune cells, and cell interactions that lead to scarring. Using advanced tools to study individual cells and their locations in the body, our research helps reveal promising targets for future therapies. 

Immunofluorescence image of a diabetic foot ulcer.
Immunofluorescence image of a diabetic foot ulcer (credit: Dr Jenna Cash)

Chronic inflammation and autoimmunity

A key focus is understanding how long-term (chronic) inflammation and autoimmunity contributes to human diseases like chronic liver and kidney diseases, chronic skin wounds, arthritis, pulmonary fibrosis and cancer. We also study the roles of ageing cells, impaired repair, dysregulation of immune cells, and cell interactions that lead to scarring. 

Using advanced tools to study individual cells and their locations in the body, our research helps reveal promising targets for future therapies. 

AI image of arthritis inflammation on joints in a pair of hands

Researchers in this theme

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